Sorteberg, Hilde-Gunn Opsahl and Nielsen, Kåre Magnus and Meadow, Richard and Junttila, Olavi and Brandtzæg, Per and Vikse, Rose and Sipinen, Ville Erling and Sanden, Monica and Mikalsen, Arne and Finne, Merethe Aasmo and Dalen, Knut Thomas and Dahl, Knut Kelkås and Bakke, Anne Marie and Andreassen, Åshild Kristin (2021) Final Health and Environmental Risk Assessment of Genetically Modified Soybean A2704-12. European Journal of Nutrition & Food Safety, 13 (1). pp. 115-116. ISSN 2347-5641
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Abstract
Soybean A2704-12 expresses the phosphinothricin-N-acetyltransferase (pat) gene, from the soil bacterium Streptomyces viridochromogenes. The encoded PAT protein confers tolerance to the active herbicidal substance glufosinate-ammonium. Bioinformatics analyses of the inserted DNA and flanking sequences in soybean A2704-12 have not indicated a potential production of putative harmful proteins or polypeptides caused by the genetic modification. Genomic stability of the functional insert and consistent expression of the pat gene have been shown over several generations of soybean A2704-12. With the exception of the intended changes caused by the transgenetically introduced trait, data from field trials performed in the USA and Canada show that soybean A2704-12 is compositionally, morphologically and agronomically equivalent to its conventional counterpart and to other commercial soybean varieties. A repeated dose toxicity study in with rats and a nutritional assessment trial with broilers indicate that soybean A2704-12 is nutritionally equivalent to and as safe as conventional soybean varieties. The PAT protein produced in soybean A270412 does not show sequence resemblance to known toxins or IgE-dependent allergens, nor has it been reported to cause IgE-mediated allergic reactions. Soybean is not cultivated in Norway, and there are no cross-compatible wild or weedy relatives of soybean in Europe.
Based on current knowledge, the VKM GMO Panel concludes that with the intended usage, there are no discernible safety concerns associated with soybean A2704-12 regarding human or animal health or to the environment in Norway.
soybean (Glycine max) A2704-12 EFSA/GMO/NL/2005/18 herbicide tolerance pat food and feed safety environmental risk Regulation (EC) No 1829/2003 VKM risk assessment Norwegian Scientific Committee for Food Safety Norwegian Environment Agency.
Item Type: | Article |
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Subjects: | e-Archives > Agricultural and Food Science |
Depositing User: | Managing Editor |
Date Deposited: | 25 Oct 2022 12:02 |
Last Modified: | 04 Jun 2024 11:23 |
URI: | http://ebooks.abclibraries.com/id/eprint/31 |